Actor Eric Dane dies at 53 after battle with ALS

Eric Dane, the celebrated actor best known for his roles on “Grey’s Anatomy” and “Euphoria” and who later in life became advocate for ALS awareness, died Thursday. He was 53.

His representatives said Dane died from amyotrophic lateral sclerosis, known also as Lou Gehrig’s disease, less than a year after he announced his diagnosis.

Dane developed a devoted fanbase when his big break arrived in the mid-2000s: He was cast as Dr. Mark Sloan, aka McSteamy, on the ABC medical drama “Grey’s Anatomy,” a role he would play from 2006 until 2012 and reprise in 2021. In 2019, he did a complete 180 from the charming McSteamy and became the troubled Cal Jacobs in HBO’s provocative drama “Euphoria,” a role he continued in up until his death.

Dane also starred as Tom Chandler, the captain of a U.S. Navy destroyer at sea after a global catastrophe wiped out most of the world’s population, in the TNT drama “The Last Ship.” 

In April 2025, Dane announced he had been diagnosed with ALS, a progressive disease that attacks nerve cells controlling muscles throughout the body.

ALS gradually destroys the nerve cells and connections needed to walk, talk, speak and breathe. Most patients die within three to five years of a diagnosis.

Dane became an advocate for ALS awareness, speaking a news conference in Washington on health insurance prior authorization. “Some of you may know me from TV shows, such as ‘Grey’s Anatomy,’ which I play a doctor. But I am here today to speak briefly as a patient battling ALS,” he said in June 2025. In September of that year, the ALS Network named Dane the recipient of their advocate of the year award, recognizing his commitment to raising awareness and support for people living with ALS.

Dane was born on Nov. 9, 1972 and raised in Northern California. His father, a Navy man, died of a gunshot wound when he was 7. After high school, he moved to Los Angeles to pursue acting, landing guest roles on shows like “Saved by the Bell,” “Married...With Children,” “Charmed” and “X-Men: the Last Stand,” and one season of the short-lived medical drama “Gideon’s Crossing.”

Dane is survived by his wife, actor Rebecca Gayheart, and their two teen daughters, Billie Beatrice and Georgia Geraldine. Gayheart and Dane wed in 2004 and separated in September 2017.

A memoir by Dane is scheduled to be published in late 2026.



(Photo Jordan Strauss/Invision via AP)