The 26-year-old former Cal State Northridge player closed with a 1-under 71 for a two-stroke victory. She finished at 10-under 206 and earned $19,500 to jump from 12th to seventh on the money list with $56,656. The top 10 at the end of the season will earn LPGA Tour cards.
Guce birdied the par-5 sixth and 14th and bogeyed the par-4 12th in the final round. She won the Danielle Downey Credit Union Classic last month in Rochester, New York.
Jackie Stoelting and Laura Gonzalez Escallon tied for second. Escallon had a 67, and Stoelting shot 70. Stoelting also has two victories this year.
Nelly Korda (71), Erica Popson (72) and Wichanee Meechai (67) tied for fourth at 7 under, and Kendall Dye (72) was another stroke back along with Brittany Marchand (67) and Pavarisa Yoktuan (72).
Princeton's Emma Talley shot a 71 on Sunday and finished in a tie for 25th at 3 under.