Added to the U.S. Solheim Cup team Monday as one of Juli Inkster's two captain's picks, Lang had a two-stroke lead over Tiffany Joh, Sydnee Michaels and Ryann O'Toole.
Lang birdied Nos. 1, 3-5 and 7 in her morning round on the Senator Course at the Robert Trent Jones Golf Trail's Capitol Hill complex. She birdied Nos. 11-12, dropped strokes on Nos. 13-14 and rebounded with birdies on Nos. 16-17.
Julieta Granada, Hyo Joo Kim, Ariya Jutanugarn, Therese Koelbaek and Simin Feng were three strokes back at 68.
Stacy Lewis, the 2012 winner, had a 70. Second last year in Prattville, she's coming off a playoff loss to Lydia Ko last week in the Canadian Pacific Women's Open.
Lexi Thompson, the 2011 winner at age 16, opened with a 69. Caldwell County alum Emma Talley shot 74 on Thursday and sits at 2 over.