Jose Abreu hit another long home run for the White Sox, but it was Semien's first career slam that turned around the game. Detroit starter Drew Smyly allowed two runs in six innings, but Evan Reed (0-1) gave up two singles and a walk, and Ian Krol allowed the home run to Semien.
Andre Rienzo (1-0) gave up four runs in the fourth inning but kept the Tigers quiet otherwise in his first start this season. He allowed five hits and two walks in 6 1-3 innings, striking out three.
Matt Lindstrom pitched the ninth for his third save, but it wasn't easy. He allowed a single, a walk and two deep flyouts before retiring Alex Avila on a line drive to first with runners on second and third.