The Reds opened the season with a three-game sweep of the Pirates at Great American Ball Park. They improved to 4-0 on Thursday night by taking advantage of struggling A.J. Burnett (8-5), sending the Pirates to their most lopsided loss of the season.
Pittsburgh hadn't allowed so many runs since a 15-5 loss to Arizona on Aug. 17, 2013.
Marlon Byrd also hit a three-run homer, and Jay Bruce drove in three runs with a sacrifice fly and a double as the Reds improved to 8-2 overall against the Pirates this season.
Left-hander David Holmberg (1-0) was called up from Triple-A and allowed two runs and five hits in six innings.