Ortiz's two-run shot to right field off Carlos Rodon in the fifth inning tied him with Gary Sheffield for 25th all-time. It was his sixth homer of the season and 451st with Boston, one off Carl Yastrzemski's club mark.
Ortiz added an RBI single in the seventh against Zach Duke, and embattled Clay Buchholz (1-3) was sharp over seven innings in Boston's fourth win in five games.
Jose Abreu's two-run homer in the first was the only blemish for Buchholz, who allowed three hits and struck out six.
