The Colts (3-4) came in having lost two of three, including blowing a 14-point lead in an overtime loss last week at Houston. But Luck has never lost to Tennessee, and he improved to 8-0 against the Titans with yet another comeback win. He finished with 353 yards passing and three TDs, the last after Tennessee went up 23-20.
T.Y. Hilton caught seven passes for 133 yards, including a 37-yard TD. The Colts shook off 12 penalties for 131 yards in pulling out their 15th win in 16 games against Tennessee.
The Titans (3-4) saw their two-game winning streak end.
Marcus Mariota had a chance to rally the Titans, but T.Y. McGill sacked him and stripped out the ball. Robert Mathis picked it up and ran 14 yards for the clinching TD with 1:47 left and a 34-23 lead. The Colts finished with three sacks.