Anthony Rizzo hit a two-run homer as Chicago improved to 5-2 on its nine-game home stand. Kyle Schwarber and Jason Heyward also connected, helping the Cubs bounce back from their 6-4 loss to the Giants on Monday night.
Lester and Cueto hooked up in a memorable pitchers' duel in Game 1 of the NL Division Series last October, with Chicago winning 1-0 on Javier Baez's eighth-inning homer. The Cubs eliminated the Giants in four games and went on to their first World Series title in 108 years.
Lester (3-2) was sharp once again in the low-profile reunion. Cueto (4-4) was just OK, striking out eight in six innings, but surrendering each of Chicago's three homers.
