Leake (3-1) gave up three hits and three walks while striking out six. He scored a run in the third inning and his two-run single capped a three-run fourth when St. Louis took a 4-2 lead.
The Cardinals took advantage of six walks by starter Jimmy Nelson (1-1) and an error by the Brewers for their first four runs. They made it 6-2 in the eighth on RBI singles by Fryer and pinch-hitter Matt Adams.
Manny Pina opened the ninth inning for Milwaukee with his first homer and Jonathan Villar added an RBI single.
