In a matchup between the teams with baseball's longest championship droughts, the Indians scored twice in the first inning off October ace Jon Lester and were on their way.
With the score 3-0, AL Championship Series MVP Andrew Miller escaped a bases-loaded, no-out jam in the seventh and got out of trouble in the eighth.
Perez drove in four runs from the No. 9 spot and Francisco Lindor got three hits.
The Game 1 winner has taken the title in the last six Series and 17 of 19.
Trevor Bauer, trying to come back from a sliced pinkie, starts Game 2 for the Indians on Wednesday night against Jake Arrieta. With rain in the forecast, the start time has been moved up an hour to 6:08 pm CT.
