The All-Star forward carried more of the load than usual with Westbrook and Anthony sidelined. Westbrook missed the game with a sprained left ankle and Carmelo Anthony sat out with a sprained right ankle. George responded by making 10 of 24 shots and adding eight assists.
Alex Abrines scored 16 points and Raymond Felton, Jerami Grant and Patrick Patterson each added 14 for the Thunder. They had lost five of six and were falling in the Western Conference standings.
Marc Gasol scored 18 points, and JaMychal Green added 14 for the Grizzlies. They have lost six in a row.
The Thunder had one of their most productive offensive halves of the season to lead 74-54 at the break. George scored 22 points and Abrines added 16 as Oklahoma City shot 59 percent from the floor and made 12 of 17 3-pointers in the first half.
The Thunder bolted out of the gate with an 8-0 run to start the second half that included 3-pointers by George and Felton. Oklahoma City pushed its lead to 28 in the third quarter and took a 95-80 advantage into the fourth quarter. A lob from Felton for a dunk by rookie Terrance Ferguson pushed Oklahoma City's edge to 102-80.
