The Eagles (9-3) opened with quick drives of 80 and 88 yards for touchdowns. They took sole possession of the division lead with four games remaining, including a rematch in less than three weeks.
Tony Romo looked ragged in the first quick turnaround for his surgically repaired back as the Cowboys (8-4) lost their third straight home game.
McCoy, who led the NFL with 1,604 yards last season, had his fourth 100-yard game in the past seven after going without one the first five weeks and secured his fourth 1,000-yard season since 2010.
