The Reds won for the seventh time in nine games and reached .500 at 11-11.
The Pirates have lost six of seven, scoring a total of 22 runs in that span.
Cingrani (2-2) allowed one run and six hits in six innings. He struck out seven and walked two.
Ludwick's double in the sixth drove in Joey Votto and Todd Frazier. Both of them were plunked by rookie Brandon Cumpton (0-1), promoted from Triple-A earlier in the day.