Altherr returned to the lineup after missing the first 103 games of the season with a broken left wrist. He went 3 for 4 with two RBIs.
Braves starter Matt Wisler (4-11) gave up three homers and has allowed eight homers in his past four starts, a span of 20 1/3 innings.
Atlanta, with the worst record in the major leagues, dropped to 14-37 at home.
