The Lyons had a balanced offensive attack, led by Brady Kirk's 19 points, along with 18 apiece from Nolan Coffman and Isaac Defew.
The Lyons also dominated the boards 53-27.
Lyon County (12-2) will face Pineville (14-5) in the quarterfinals on Friday at 5 p.m.
The Ballard Memorial Bombers lost in the opening round of the boys All "A" Classic to Walton-Verona 64-45.
Jace Birney led the Bombers with 22 points
In girls state quarterfinal action on Friday, the Crittenden County Lady Rockets take on Whitefield Academy at 1 p.m.
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