The Titans (33-3), also got 11 points and 11 rebounds from Emmy Souder. The Titans will face Owensboro Catholic in Friday's quarterfinals.
Mercer led 30-25 at halftime and stretched the lead to 18 in the fourth quarter. Murray (32-3) fought back and cut the lead to eight late, but could get no closer.
Murray finished the game just 5-for-30 from 3-point range. Alexis Burpo led the Lady Tigers with 14 points, 15 rebounds and six assists.
