Taya Reimer had 19 points and 10 rebounds and Ariana Simmons added 14 points for Indiana, who split with Kentucky in the All-Star series for the second straight year.
Makayla Epps had 23 points and Larryn Brooks had 19 for Kentucky.
Indiana went on an 11-2 run at the end of the first half and beginning of the second to build a 10-point lead. Perry scored two free throws with 18:45 left and then a basket to give Indiana a 46-36 lead. Indiana never looked back.
Indiana played without Miss. Basketball Stephanie Mavunga, who sprained her left knee in Indiana's loss in Kentucky on Friday.