After scraping past George Mason and Nebraska-Omaha, the Cardinals (3-0) had a surprisingly easy time against the Salukis (2-1) after the early moments. They turned a 9-6 deficit into a 29-18 halftime lead before putting put it out of reach, leading 65-30 with 6:47 remaining.
Though the teams combined to shoot just 11 of 47 from behind the arc, Louisville's freshmen found their mark late to finish 8 of 26. Nwora had 12 points combined coming in but made 7 of 10 shots and had eight rebounds.
Louisville held SIU to 27 percent shooting, including just 3 of 21 from long range.
Dwayne Sutton had eight points with two 3s, guard Darius Perry had 10 points and forward Lance Thomas added one from deep.
Armon Fletcher had 14 points and seven rebounds for SIU while Kavion Pippen, nephew of NBA great Scottie Pippen, had 10 points.