The Cardinals (5-0) were in a back-and-forth game with the Billikens (4-1) until they turned to full-court pressure and kept up their huge rebounding advantage.
Louisville led 30-27 at halftime and the lead was the same when the Cardinals finally put a run together. Lewis and Damion Lee, the two graduate transfers on Louisville's roster, had four points each in a 10-0 run that made it 51-38. The Billikens never got closer than 10 points the rest of the way.
Mike Crawford led Saint Louis with 20 points on 7-of-9 shooting, including 4 of 5 on 3s. Milik Yarbrough added 14 points.
