The Rockets collected 538 total yards and were 6 of 13 on third-down conversions while maintaining possession of the ball (27:44) for less than half the game.
Guadagni was 18-of-25 passing while backup Carter Bradley threw for 82 yards and a touchdown. Toledo (1-1) led 17-0 at halftime and then broke it open with a three-touchdown third quarter. Guadagni threw a 43-yard touchdown pass to Desmond Phillips, Bryant Koback had a 7-yard TD run and Bradley threw a 55-yard score to Danzel McKinley-Lewis.
Murray State's (1-2) Preston Rice was 26-of-36 passing for 180 yards with two interceptions.
It was the first-ever meeting between the two schools. The Rockets are 25-2 against FCS opponents since the NCAA split up Division I in 1978.